Manually-curated safety data to support target prioritisation
Throughout the drug discovery and development process, target safety assessments help with understanding the role of the drug target in normal physiology and potential unintended adverse consequences and safety liabilities when modulating the target with a chemical compound or drug (Brennan, 2017).
To support target prioritisation, we have manually curated experimental data and insights from publications and other well-known sources of target safety and toxicity data, including the ToxCast database.
Safety data is available on the target profile page and can be accessed to provide a systematic view of potentially relevant target safety liabilities.
Target safety datasets are mapped to the correct Ensembl gene ID and ingested during our initial pipeline steps to enrich the target annotation object. The data is available for download as part of the target core annotation from our data download page.
Brennan R.J. (2017) Target Safety Assessment: Strategies and Resources. In: Gautier JC. (eds) Drug Safety Evaluation. Methods in Molecular Biology, vol 1641. Humana Press, New York, NY. doi: 10.1007/978-1-4939-7172-5_12
Ann M. Richard, Richard S. Judson, Keith A. Houck, Christopher M. Grulke, Patra Volarath, Inthirany Thillainadarajah, Chihae Yang, James Rathman, Matthew T. Martin, John F. Wambaugh, Thomas B. Knudsen, Jayaram Kancherla, Kamel Mansouri, Grace Patlewicz, Antony J. Williams, Stephen B. Little, Kevin M. Crofton, and Russell S. Thomas. ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. Chemical Research in Toxicology 2016 29 (8), 1225-1251. doi: 10.1021/acs.chemrestox.6b00135. PMID: 27367298.
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Urban L, Whitebread S, Hamon J et al. Screening for safety-relevant off-target affinities. In: Polypharmacology in Drug Discovery. Peters JU (Ed.). John Wiley and Sons, NJ, USA (2012). doi: 10.1002/9781118098141.ch2.